Shinichi Kudou, a remarkable high school student with an exceptional talent for detective work, gained fame for his impressive track record in solving challenging cases. One fateful day, he unwittingly witnesses a heinous illegal activity while tailing two suspicious men. Unfortunately, he was caught in the act and subjected to an experimental drug concocted by a criminal syndicate, which was meant to kill him. Against all odds, Shinichi miraculously survives the ordeal, but his body is reduced to that of a seven-year-old child, while his cognitive abilities remain intact.

Determined to keep his true identity a secret from everyone, even his childhood friend Ran Mouri and her father, private detective Kogorou Mouri, Shinichi assumes the name Conan Edogawa, which pays homage to famous mystery writers Arthur Conan Doyle and Ranpo Edogawa. Despite his physical limitations, he continues to solve cases for Kogorou from behind the scenes, utilizing his unparalleled detective skills, all while covertly investigating the organization responsible for his predicament in the hopes of eventually finding a cure for his condition.